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GSK’s two-drug HIV therapy shines in two big studies

2 January 2017 11:51 am - 0     - {{hitsCtrl.values.hits}}

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REUTERS: GlaxoSmithKline’s already fast-growing HIV drug business has received an important boost after two major clinical studies successfully tested a new two-drug treatment regimen to control the virus that causes AIDS.
The approach is a departure from conventional triple drug cocktails that can cause troublesome side effects, especially among older patients who make up a growing proportion of those treated for the disease.
Antiretroviral therapy has turned HIV from a death sentence into a manageable condition but patients need to stay on treatment for life, so there is a growing focus on making medication as well-tolerated as possible. 
GSK has developed the new two-drug cocktail through its majority-owned ViiV Healthcare, in which Pfizer and Shionogi also hold stakes. The aim is to offer the two-drug regimen as a single tablet. Easing back from triple therapy is the opposite approach to that being pursued by HIV market leader Gilead Sciences, which is banking on improving triple regimens. “The key debate remains whether Gilead will gain the upper hand again or whether a disruptive two-drug regimen becomes standard of care, favoring GSK,” said UBS analyst Michael Leuchten. In addition to developing its new two-in-one HIV tablet, GSK is also working on long-acting drug injections for both treating and preventing HIV.
Results of the two Phase III tablet studies, announced late on Monday, showed that the combination of GSK’s dolutegravir and Johnson & Johnson’s rilpivirine worked as well as three- or four-drug regimens.
Dominique Limet, chief executive of ViiV, said the results were “an important milestone in our understanding of how HIV can be treated”, since they represent the first late-stage trial evidence for the two-drug approach.

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