A huge fire has engulfed a tower block in Latimer Road, west London, with eyewitnesses claiming people are trapped in their homes.
The fire at Grenfell Tower on the Lancaster West Estate was reported at 01:16 BST and about 200 firefighters are tackling the blaze.
The Met Police said people were being treated for "a range of injuries".
The BBC's Andy Moore said the whole tower block was alight and there are fears the building might collapse.
London Fire Brigade sent 40 fire engines to the tower.
Eyewitnesses said they could see lights - thought to be torches - flashing at the top of the block of flats, which people say is "close to burning through".
George Clarke, the presenter of Channel 4 TV programme Amazing Spaces, told Radio 5 Live: "I'm getting covered in ash, that's how bad it is.
"I'm 100 metres away and I'm absolutely covered in ash.
"It's so heartbreaking, I've seen someone flashing their torches at the top level and they obviously can't get out."
Tim Downey, another eyewitness, told the BBC part of the building was "completely burned away".
"It has burned through to its very core," he said.
"It looks very bad, very very bad. I've never seen anything like this. It's just such a big fire.
"The whole building is just crumbling. It's just billowing black smoke." (BBC)
Devaka Wednesday, 14 June 2017 11:14 AM
England is reaping the harvest of " Sanhindiyawa " at its best . All liberal political theories are coming to an end.
ANTON Wednesday, 14 June 2017 11:19 AM
ENGALANTHEY EHEMA UNATH , ...... LANKAAVEY EHEMA VENNEY NAA, ........ SUDDANTA ENDA KIYAMU, APEY RATA BALANDA KIYAMU.......
prabayh Wednesday, 14 June 2017 11:23 AM
Another islamic attack via DM Android App
ceylon Wednesday, 14 June 2017 11:24 AM
no reason to buikd building over 50 floors.high risk of fire accidents.no safe living. via DM Android App
BURDEN OF PROOF Wednesday, 14 June 2017 02:09 PM
" ei incumbit probatio qui dicit, non qui negat " (the burden of proof is on the one who declares, not on one who denies)
Religious conotation ? Wednesday, 14 June 2017 02:22 PM
Islamic ? how come - cannot it be a "christian" attack (by the remnants of the IRA } as Theresa is breaking the agreement on North Ireland by trying to team up with a Irish political party.
Kale Wednesday, 14 June 2017 05:58 PM
This will happen in Sri Lanka soon enough with all the tower blocks going up.High standards but low enforcement, owners who will only want to save money and builders who can always buy their way out of trouble.
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